Versatility of cell-penetrating peptides for intracellular delivery of siRNA
نویسندگان
چکیده
منابع مشابه
Human DMBT1-Derived Cell-Penetrating Peptides for Intracellular siRNA Delivery
Small interfering RNA (siRNA) is a promising molecule for gene therapy, but its therapeutic administration remains problematic. Among the recently proposed vectors, cell-penetrating peptides show great promise in in vivo trials for siRNA delivery. Human protein DMBT1 (deleted in malignant brain tumor 1) is a pattern recognition molecule that interacts with polyanions and recognizes and aggregat...
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The binding affinity of a series of cell-penetrating peptides (CPP) was modeled through docking and making use of the number of intermolecular hydrogen bonds, lipophilic contacts, and the number of sp3 molecular orbital hybridization carbons. The new ranking of the peptides is consistent with the experimentally determined efficiency in the downregulation of luciferase activity, which includes t...
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ژورنال
عنوان ژورنال: Drug Delivery
سال: 2018
ISSN: 1071-7544,1521-0464
DOI: 10.1080/10717544.2018.1543366